Dextromethorphan Withdrawal and Dependence Syndrome
نویسندگان
چکیده
منابع مشابه
Dextromethorphan attenuates ethanol withdrawal syndrome in rats.
The effects of dextromethorphan (DM), a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptors, have been investigated on ethanol withdrawal signs in rats. Ethanol (7.2% v/v) was given to rats in a liquid diet for 16 days. DM (10, 20, and 40 mg/kg) and saline were injected intraperitoneally at the third hour of ethanol withdrawal. DM (40 mg/kg) and ethanol dependent saline were ...
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Recent studies have shown that NMDA receptors are involved in the tolerance and dependence to opioids. In addition, it has been reported that ketamine, dextromethorphan and amantadine have antagonistic activity at NMDA receptors. Therefore, this study was conducted to clarify the effect of these drugs on morphine withdrawal syndrome. Morphine dependence was induced by increasing doses of morphi...
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ژورنال
عنوان ژورنال: Deutsches Aerzteblatt Online
سال: 2010
ISSN: 1866-0452
DOI: 10.3238/arztebl.2010.0537